Sentence examples for mutational inactivation in from inspiring English sources

The vertebrate ept gene homolog, TSG101, was first identified based on its ability to inhibit cell transformation [9] and by its apparent mutational inactivation in some cancers [10].

The Waf1 gene is not a frequent target for mutational inactivation in breast (or other) cancers [ 29].

The downstream signal transduction Smad proteins are also targets of mutational inactivation in some human cancers [ 37].

PKS I positive inserts were then cloned into pK18mob2 34 and used for mutational inactivation in Verrucosispora maris AB-18-032 by single crossover recombination.

Its mutational inactivation in humans causes autosomal recessive cutis laxa type 1C (ARCL1C), which is a severe disorder caused by defects of the elastic fiber network.

Our data indicate that loss of STAG2-cohesin function in mediating chromatid cohesion is unlikely to be the major effect of mutational inactivation in bladder cancer.

In this malignancy, mutational inactivation of FBXW7/hCDC4 in combination with NOTCH1 mutations predicts a favorable outcome [ 15, 47].

Importantly, this cell cluster continues to express Acj6 immunoreactivity following mutational inactivation of otd in the LALv1 lineage.

Results The authors show that mutational inactivation of Sesn2 in mice prevents cigarette-smoke-induced pulmonary emphysema.

However, recent identification of p27Kip1 mutations in breast cancer [ 10] and multiple endocrine neoplastic syndromes [ 11] raises an interesting new possibility that mutational inactivation of p27Kip1 in other tumour types cannot be completely ruled out [ 12].

While mutation of the P53 tumour suppressor gene is a common feature of many types of cancer [ 4], mutational inactivation of P53 in melanoma is uncommon and wild-type P53 is frequently expressed at high levels [ 5- 9].