Sentence examples for mutational impacts of from inspiring English sources

Not surprisingly, comparative sequence analysis of the multiple alignments clearly indicated that the average mutational impacts of substitutions on the flexibility of codons (dTRX) were far greater, in those four substitution types which alter the local GC content.

However, these author's conclusions are not based on any direct analysis of mutational impacts on DNA shape or flexibility.

To further investigate the importance of mutational impacts on codon flexibility (dTRX) in driving common patterns observed in comparative genomics, we averaged the |dTRX| for the coding region of each gene and compared avg|dTRX| with Ts Tv ratios and levels of functional conservation on proteins (i.e., d N and d N/d S).

We investigated directly the potential role that codon assignments in the standard genetic code may play in biasing mutational impacts on DNA flexibility at the level of codons.

To examine the mutational impact of the classical strain improvement (CSI) program on the genome of P. chrysogenum, we sequenced the genomes of four P. chrysogenum strains.

This link between CGIs and ORIs together with a mutational impact of replication should leave a footprint on substitution patterns along the genome.

Later, we outline two lines of supporting evidence that DNA shape and flexibility are subject to significant evolutionary forces both from neutral mutational bias imposed by the genetic code itself and from purifying selective pressure to generally minimize mutational impacts on DNA flexibility.

Our structure now provides a platform for the analysis of mutational impact on structure, ligand binding, and regulation of α-actinin in inherited human diseases (see Supplemental Information and Figure S7).

In their paper " Pathway-driven discovery of rare mutational impact on cancer," T. Ahn and T. Park suggested a new approach for discovering rare mutations that have real impact in the context of pathway, which could sensitively capture mutations that change pathway level of mRNA expression.

The genomes of the subjected strains were sequenced using the Illumina next generation technique that allowed us to determine the mutational impact on P. chrysogenum during CSI.

To assess potential influences of selective constraints on dTRX, we also included average random mutational impacts estimated from the real patterns of mutation in the yeast genomes as well.