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Thus, despite our best efforts, retrospective mutational examination of any additional patients in our series is unfortunately not possible.
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Deep sequencing has the potential to reveal the mutant spectrum within a viral sample at high resolution, thus enabling the close examination of viral mutational dynamics both within- and between-hosts.
Furthermore, examination of the mutational load in this strain, which was generated as part of the Million Mutation Project (Thompson et al. 2013), revealed no obvious strong loss-of-function mutations in genes known to influence aging or RNAi (Table S19).
An examination of the NCL mutational database for LINCL has shown only one mutation involving W residues in the TPPI (http://www.ucl.ac.uk/ncl).ac.uk/ncl
Examination of K-RAS mutational status and EGFR gene copy number in 26% of patients from this trial failed to identify either change as molecular predictors of response [ 160].
Histopathological examination of clinical samples, characterization of the mutational landscape of various types of cancer and functional studies in cancer cell lines have highlighted the linker histone H1 both as a potential biomarker and a driver in cancer.
A panel of 21 p53 gene mutation assays (MAP or Bi-PAP-A) may detect the mutational signature in ∼30% of breast cancers, based on an examination of data from the IARC TP53 database (www-p53.iarc.fr).
Thus, examination of the distribution of EMS-induced changes revealed the mutational and recombinational history of the chromosome, even generations later.
A fusion of the C-terminal zipper region of GCN4-bZIP with the N-terminal cap of PYP was designed based on examination of available crystal structure data, analysis of amino acid preference rules for leucine zippers, and mutational and amino acid conservation data for PYP, together with Rosetta-guided structural modeling.
They typically disregard information in reads mapping to repeat sequences, and significant post-processing and manual examination of their output is often required to rule out false-positive predictions and precisely describe mutational events.
An examination of my coat.
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