Sentence examples for mutational events that from inspiring English sources
We evaluate recurrent prostate-specific mutations prior to discussing the mutational events that are shared both in prostate cancer and across multiple cancer types.
This linear path of clonal expansions is arguably simplistic and only conveys the key mutational events that drive progression, namely 'driver' mutations.
This enabled a global view of all mutational events that occurred in human mtDNA phylogeny (excluding ambiguous mutations, that is, mutations in which there is no certainty as to the identity of the nucleotide changes).
We also investigated impact of rare mutations on drug target pathways; we found two mutational events that consisted of two and three genes.
Finally, dynamic/stochastic effects might be responsible, i.e., a less-effective immune escape mutation might initially be more common due to random mutational events that preceded immune selection [16].
Thus, the hprt locus is a useful target for the study of chemical-specific mutational events that may help identify causes of background mutation in human cells in vivo.
Recently, on the basis of the unusual DNA sequence organization of the DRD4 7R 48-bp tandem repeat (VNTR), we proposed that the 7R allele originated as a rare mutational event that increased to high frequency by positive selection.
This suggested that the disease was the result of a single mutational event that had been spread through the population by the champion sire effect.
The agreed sequence of events in human tumours involves a mutational event that leads to an MMR gene abnormality thus causing the MSI phenotype that then by chance hits an MBD4 allele.
On the other hand, a mutational event that occurred early in replication and conveyed an intracellular replication advantage could potentially give rise to hundreds or thousands of descendant virions in a single generation.
Each colony arose from a mutational event that overcame whatever prevented growth (e.g., inability to utilize the nutrients provided or to synthesize a needed biochemical).
