Sentence examples for mutational environment in from inspiring English sources

Indeed, CIN is seen in the majority of human cancers and is thought to play a role early in oncogenesis by creating a mutational environment in which the necessary oncogenes or tumor-suppressor genes are more likely to be mutated and enable a malignant tumor phenotype (Stratton et al. 2009).

However, GC-to-AT and AT-to-GC mutations did not differ in plastome sequences (t-test, P = 0.379), suggesting different mutational environments between nupts and their corresponding plastome sequences.

The use of 1000 genotypes viable on multiple environments allows us to estimate also the distribution of mutational robustness in multiple environments.

The results strongly imply that genes in quadrants A and B are not only atypical in their current environments, but also highly similar to the external and internal mutational pressures in the other environment.

However, it also cannot be ruled out that these dissimilarities result from underlying mutational differences in laboratory versus natural environments.

Put generally, the joint distribution of mutational rates and effects across genotypes and environments is required (Martin et al. 2013), expanding to many environments in models with spatial structure or continual temporal change.

Clades exhibiting fast substitution rates may therefore be more likely survive rapidly changing or novel environments, in spite of the fact that they otherwise have increased chances of extinction because of their relatively higher levels of mutational genetic load.

Mutational analysis in the desmoplastic melanoma cohort.

From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.

In further studies, he identified aristolochic acid's mutational signature in DNA from patients' tumors.

Analysis of mutational clonality in 55 NF1-glioma samples.