Sentence examples for mutational effects of from inspiring English sources

In this study, we have established an in vivo assay system to analyze mutational effects of Ralstonia eutropha polymerase (termed PhbCRe) on the level of PHB accumulation in recombinant strains of Escherichia coli.

Among the main findings are a major conformational change (>20 Å) in the catalytic loop, which revealed a gatinglike dynamics, and a transient intraloop structure, which provided a rationale for the mutational effects of several residues on the loop including Q148, P145, and Y143.

The mutational effects of other amino acid changes, however, are less straightforward, in part because the regulation mechanism of irrE itself has not been elucidated.

Evidence comes from the study of mutational effects of individual proteins [ 25].

Streamlining but also quenching of the mutational effects of neutral genes are important in load reduction.

(A) We stated that we pooled the mutational effects of repairing each type of lesion.

This is based on a simple model of Muller's ratchet that accounts for the distribution of mutational effects on fitness, the availability of multiple copies of the genome and mitotic recombination.

One of these DMEs needs to be a low-level DME like the distribution of mutational effects on the kinetic properties of a given enzyme.

Nonetheless, the overall agreement between mutational effects on modification of the two distinctive substrates suggests that a specific HECT domain architecture is generally important for Rsp5-mediated Ub ligation.

Addressed topics include the distribution of mutational effects on fitness, as well as the nature of advantageous mutations, epistasis and robustness.

2. Choose a realistic distribution of mutational effects on the kinetic parameters to model the effects of changes in DNA sequences on kinetic parameters (see discussion below).