Sentence examples for mutational disruption of from inspiring English sources
Mutational disruption of this interaction in full-length PKG implicates the switch helix as a critical site of dimer communication in PKG biology.
Par-6 PDZ regulation is required for function as mutational disruption of Cdc42-Par-6 PDZ coupling leads to inactivation of Par-6 in polarized MDCK epithelial cells.
In doing so, our work characterizes targetable molecular pathways mediating well-established malignant behavior in diffusely infiltrating astrocytic gliomas, while also revealing discrete examples of how mutational disruption of chromatin regulation impacts the expression of tumor-specific biology.
Here we provide additional evidence that mutational disruption of these sites does not dramatically alter the endogenous mRNA levels of NQO1, HO-1 or GCLM (Figure 3C), excluding possibilities that phosphorylation might interfere with molecular events that are specific to native chromosomal architectures.
Consistent with our data, Zipper and Mulcahy showed that mutational disruption of six MAPK consensus sites in Nrf2 (including S215, S408, S577 that were also characterized in this study) failed to significantly change the GCLM ARE-dependent reporter gene activities in the absence or presence of pyrrolidine dithiocarbamate (PDTC), an Nrf2 inducer [34].
Using combinations of computational and experimental approaches, different research groups have identified many putative ESEs and ESSs and demonstrated their ability to modify exon inclusion levels, either by insertion of ESRs into reporter minigenes, or by mutational disruption of ESRs in naturally occurring exons [29] [36].
The PT rates are significantly impacted by both mutational disruptions to internal hydrogen bond networks and the presumed structural rigidity of β-strand 7 as probed by circular permutation.
Even without mutational disruption, the reactive state of an autoprocessing system may be insufficiently populated for characterization by X-ray crystallography.
Our structural and mutagenic analyses of the PER2-CBD-CRY2 complex reveal a surprisingly robust binary assembly, which is resilient to mutational disruption.
This suggests that biological systems have evolved to have a high degree of robustness to mutational disruptions that can affect the majority of their genes.
We compared the response of Escherichia coli to environmental and mutational stress following disruption of random or hub genes.
