Sentence examples for mutational destabilization of from inspiring English sources

Mutational destabilization of the β-finger changed mainly the dissociation rate constant of the proteins and, to a lesser extent, the association rate constant.

It has been suggested that this is an adaptation to a high incidence of mutational destabilization of proteins in these bacteria.

The stabilized stem-loop totally inhibited translation in both growth phases (No. 8), while mutational destabilization led to a constitutive high level of translation (No. 9).

Nonsense mutations also promote destabilization of mRNAs by nonsense-mediated mRNA decay (NMD).

Over 100 of such mutations have been identified, leading to destabilization of the physiological TTR tetramer.

Therefore, mutation on this position could result in destabilization of the structure.

Structural modeling and energetic analysis of the mutational hotspots have also suggested a common molecular mechanism of kinase activation by cancer mutations, which may be determined by a combined effect of the partial destabilization of the inactive state and a concomitant stabilization of the active-like form of the enzyme.

"Extreme weather events, the destabilization of the Artic.

"We are seeing a destabilization of the environment in the Arctic.

"You also saw the operations of destabilization of Rwanda at that time," he said.

Conversely, allowing the further destruction of forests feeds the further destabilization of climates.