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An examination of the NCL mutational database for LINCL has shown only one mutation involving W residues in the TPPI (http://www.ucl.ac.uk/ncl).ac.uk/ncl
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The same mutation p.Pro12Leu was found in exon 2 in two patients; according to both the IARC International Agencyy for Research on Cancer) TP53 mutational database and UMD (Universal Mutation Database) TP53 mutation database, this mutation is functional in yeast but extremely rare.
There are no known missense mutations involving the free C residue, according to the NCL mutational database (http://www.ucl.ac.uk/ncl/), indicating that this residue is not critical for TPPI catalysis.
At present, there are 68 different disease-causing mutations in the TPP1 gene among different individuals listed in the NCL mutational database (http://www.ucl.ac.uk/ncl/).ac.uk/ncl/
To address the issue of whether the different histological types of lung cancer show differences in their p53 mutational spectra, we have analysed the IARC TP53 mutation database separately for these tumors (Figure 3).
Splatalogue; Database for Astronomical Spectroscopy.
A comprehensive database for HO2.
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Mutational web databases provide essential repositories for functional, diagnostic and therapeutic approaches [ 2, 20].
Somatic mutations used to calculate the mutational burden for different cancer types were retrieved from TCGA (adult tumors) and TARGET (pediatric tumors) databases.
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