Sentence examples for mutational contributions of from inspiring English sources

In 2012, scWGA by MDA of 58 cells was used to demonstrate mutational contributions of SESN2 and NTRK1 in neoplasm progression.

For the 4 pathways that were found in BRCA by Multi-Dendrix, 2 of them also showed up in our results (PI3K-Akt signaling, MAPK signaling), the other two (p53 signaling, cell cycle) were selected as significantly mutated pathways in our Step 1 but filtered out in Step 2, as we found that the mutational contributions of these two pathways are dominated by TP53.

After deriving the core equations of the model we will discuss two specific applications of the model; an inference of the replication origin and terminus and an analysis of mutational contribution to skew.

Analysis of mutational contribution to gene expression in Caenorhabditis elegans suggested the observed variation in expression of 660 genes might be due to few trans-acting factors (Denver et al. 2005).

Second, given the influence of selection on estimates of σAT and σGC, we must limit the analysis to relatively neutral sites in order to separate the mutational contribution from selection.

Codon usage bias has been documented in a wide diversity of species, but the relative contributions of mutational bias and various forms of natural selection remain unclear.

In particular, we assemble the main data on their evolution, describing the contributions of mutational pressure, purifying, and adaptive selection, and how they are related.

Despite decades of study on codon bias the relative contributions of mutational bias vs. selection favoring the speed and accuracy of protein translation, translational robustness, or mRNA stability remains unclear (Duret 2002; Hershberg and Petrov 2008; Plotkin and Kudla 2011).

2) Do selfing species experience lower effective selection on codon bias? 3) What are the contributions of mutational biases and biased gene conversion (BGC) to patterns of codon bias?

ROC SEMPPR is grounded in population genetics and allows us to separate the contributions of mutational biases and natural selection against translational inefficiency on a gene-by-gene and codon-by-codon basis.

The relative contributions of mutational load (deleterious recessives) and segregational genetic load (overdominance) in inbreeding depression in this system is a question ripe for further study, particularly because there is only very limited evidence that overdominance may contribute significantly to inbreeding depression in life history traits [ 48, 49].