Sentence examples for mutational burden of from inspiring English sources

A similar rate of VHL mutations was observed when we assessed the mutational burden of each individual core, revealing mutations in 29/47 cores (62%).

The mutational burden of OA and RA patients was defined as the number of mutations identified within that group divided by the total number of base pairs analyzed.

Moreover, the high mutational burden of urothelial carcinoma may create numerous neo-antigens that may explain the very promising results with immune checkpoint inhibitors in early phase clinical trials.

Specifically, we address a facet of the mutational repertoire of cancers, that has not received mathematical attention, i.e. the immunological consequences of the mutational burden of tumors.

One of us has previously suggested that the mutational burden of tumors must inevitably lead to generation of tumor-specific neo-antigens that must be unique for each individual tumor because of randomness of the mutational process [7].

The mutational burden of renal tumors varies by region sampled.

From a population genetics perspective, we may expect the opposite: that small captive populations and lower Ne propagate the segregation and eventual fixation of deleterious mutations, thus, imposing a potentially large mutational burden on laboratory strains [ 36, 37].

Therefore, cumulative mutational burden for 11 investigated mitochondrial genome mutations is associated with 88.2% of cases of atherosclerotic lesions in morphologically mapped aortas.

Therefore, it is plausible to integrate both tumor and immune cell profiling with molecular data from the expression of checkpoint molecules and mutational burden to create the predictive assessments for patient selection, which may lead to an improved outcomes from immune checkpoint blockade therapy and pave the way for precision medicine to surmount NSCLC using these novel agents.

We observed a modest mutational burden, characteristic of cancers that are not associated with known carcinogens such as ultraviolet light or cigarette smoke.

The mutational burden ratio of JAK2 was calculated using the DNA and RNA copy numbers according to the following formula: JAK2V617F/ JAK2V617F +  JAK2WT).