Sentence examples for mutational burden in from inspiring English sources

RA synoviocyte mtRNA had about twice the number of mutations as the OA group, revealing a greater mutational burden in RA.

Both studies confirmed the lack of TP53 mutations compared to HPV- samples, and overall, a lower mutational burden in HPV+ disease.

Notably, DNA mismatch repair defects are a primary driver of mutational burden in heritable colorectal cancers.

We studied the mutational burden in the skeletal muscle of one subject on two occasions 10 years apart.

This issue is common to most studies that estimate the mutational burden in humans, because of the limited availability and reliability of data on prenatal loss.

Overall mutational burden in MT-HV2 was significantly higher in A467T than W748S homozygous patients (OR = 1.86, p = 0.008; Fig 6A), but A467T homozygous patients were also older, and this difference was no longer significant when corrected for age.

By sharing promoters, the gene pairs take the advantage of co-regulation albeit bearing doubled mutational burdens in maintaining their normal functions.

This suggests that the nuclear gene sequenced was not contributing to the progression of RA and that random mutations through exogenous ROS cannot, alone, explain the increase in RA mutational burden found in the mtDNA.

Although similar to previous findings in skeletal muscle, 19, 20 the mutational burden appeared higher in the brain, correlating with its more severe involvement in this type of POLG disease.

Patients in the lower risk groups tended to have a less complex mutational burden: 23.1% in low risk and 25.0% in the intermediate groups.

In particular, we aggregate the mutational burden of genes in the metabolic pathway of warfarin and demonstrate that this mutational burden explains some of the missing heritability in warfarin dose.