Sentence examples for mutational basis for from inspiring English sources
The landscape also clarified a mutational basis for RB and p53 pathway deregulation in this malignancy.
We do however think it is important to stress the mutational basis for resistance, and as such have added text in the Discussion.
Thus, while there is no mutational basis for the change in epitype, the CNR gene is potentiated for a stochastic DNA methylation event, because it contains such a large number of strategically positioned cytosine residues in its sequence.
A major hurdle in the validation of the Pig-a assay has been confirmation of the mutational basis for the observed phenotypes (i.e., GPI-anchor deficiency); however, sequencing of Pig-a mutant blood cells is not possible since RBCs lack nuclear DNA.
The subsequent study which confirmed this observation suggested a non-mutational basis for transformation to malignancy and its reversal to normalcy (Mintz and Illmensee 1975).
Not only is genome-wide sequencing valuable for finding the mutational basis of phenotypic change, but also for understanding evolutionary processes.
An exciting prospect for future work will be to dissect this physiological parallelism into its responsible constituent genes, and to learn the mutational basis of their altered regulation or function.
Our approach provides a basis for characterizing mutational signatures from cancer-derived somatic mutational catalogs, paving the way to insights into the pathogenetic mechanism underlying all cancers.
In summary, my Ph.D. thesis provided a basis for deciphering mutational signatures from cancer genomics data and developed the first comprehensive census of mutational signatures in human cancer.
The structural comparison is used to interpret the different affinities for various receptors and establishes the basis for further mutational experiments and antagonist design.
Structural and mutational analyses reveal the chemical basis for the functional properties of photoswitchable fluorescent proteins and provide the basis for subsequent coherent engineering of this subfamily of Dronpa homolog's.
