Sentence examples for mutational assessment of from inspiring English sources

Direct Sanger sequencing for mutational assessment of exon 15 of BRAF was performed following PCR amplification as previously described [ 14].

Mutational analysis or assessment of antigen damage by immunohistohemical control stainings (Battifora, 1991) could aid in selecting tumours that show completely negative staining resulting from mutations or alterations at the transcriptional or translational level.

We used a semi-quantitative analysis that incorporated both the presence and clonality of all tested LOH mutations to provide an assessment of mutational load for a given microdissected target.

Assessment of mutational load using our panel of LOH mutational markers may be a useful adjunct to microscopic inspection of biopsy specimens, and thereby, improve patient management.

The increase in p53 activity did not appear to correlate with p53 mutational status and further assessment of APR-246 needs to be made to assess its ability as a mutant reactivator [ 87].

Significant findings include an estimate for the mutation rate that is 100 times higher than generally assumed, a model for change in the major integron, and assessment of mutational, recombination, integron and other evolutionary events to the separate lineages.

Different studies have shown that this can be achieved by combining the analysis of TP53 mutational status with the assessment of other factors relevant for either mutant p53 stability or pro-oncogenic functions.

In conclusion, phenome-wide assessment of mutational variance did not provide support for universal pleiotropy, but did establish that pleiotropy generated by new, naturally occurring mutations of relatively small effect is widespread.

These data suggest that immunohistochemical assessment of H3F3A K27mutationalal status is sufficient for prognostication.

Therefore, assessment of EGFR mutational status is mandatory in order to choose the most active treatment in NSCLC patients.

In turn, an accurate assessment of MS mutational properties is essential for their effective use as genetic markers.