Sentence examples for mutational analysis in from inspiring English sources

The association of nm23-overexpression with a worse prognosis was most probably not due to mutation of the nm23 gene, since mutational analysis in 60 tumours by means of single-strand conformational polymorphism and direct sequencing disclosed only one mutation, which was located outside the open reading frame.

To further define the role of PLCE1 mutations in the etiology of FSGS, we performed mutational analysis in 69 families with FSGS.

The aims of the present study were to (1) perform a histological review of a series of lesions (initially) diagnosed as melanotic schwannoma and analyze them for GNAQ mutations, and (2) test the diagnostic value of GNAQ mutational analysis in the differential diagnosis with leptomeningeal melanocytic lesions.

We performed in silico mutational analysis in order to observe the effect of the mutations on the A2M - APP interaction, and found a possible association between abrogation of this interaction and cancer.

Initial BARD1 mutational analysis in familial and sporadic cases revealed four different germline mutations not followed by subsequent loss of heterozygosity [ 114].

In this study we carried out mutational analysis in 15 subjects of the same family and found heterozygous missense mutation in exon 41 (3040C→T, R836C) in 9 of them.

The function of histone PTMs in mammals remains uncertain because the multiple genes encoding each canonical histone, renders in vivo mutational analysis unfeasible in most instances.

In total, the mutational analysis resulted in psd module variants, which provide tuning of protein stability over a broad range by blue light.

From the result of mutational analysis (summarized in Table 2), some unique mutations at different geographical locations were found.

Fine-scale deletion and mutational analysis resulted in the definition of a very small (63 bp) promoter, making it one of the smallest active germ cell promoter sequences identified thus far.

While the identification and mutational analysis of in vivo phosphorylation sites on these substrates should yield insight into this question, our results also suggest the phosphorylation of Bni1p is related to this essential function.