The location of the cdc5-120 mutasion, as well as mutational analyses of Cef1p, indicate that the Myb repeats of cdc5p and Cef1p are important for their function in vivo.
Arabolaza, A. et al. Crystal structures and mutational analyses of acyl-CoA carboxylase beta-subunit of Streptomyces coelicolor.
Tokumoto, N. et al. Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas.
Combined kinetic and mutational analyses of structurally implicated substrate binding residues validate this binding mode.
Nicholson, S.E. et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
The spectrum of genetic changes within the "living biobank" agrees well with previous large-scale mutational analyses of CRC.
To date, our understanding of TAS2R ligand recognition has come primarily from mutational analyses of small subsets of residues or from in silico models based on crystal structures of distantly related proteins such as rhodopsin6, 16,17,18.
Mutational analyses of this region of Rho revealed that a hydrophobic pocket, located behind these amino acids of Rho, is the docking site for NusG-CTD.
A genetic interaction between miR-122 and the 5' noncoding region of the viral genome was revealed by mutational analyses of the predicted microRNA binding site and ectopic expression of miR-122 molecules containing compensatory mutations.
Previous mutational analyses of the hVDR have mainly focused on residues lining the receptor's ligand binding pocket (LBP) and techniques such as alanine scanning mutagenesis and site-directed mutagenesis.
Here, we perform systematic statistical and mutational analyses of the overlapping HIV-1 genes tat and rev and engineer exhaustive libraries of non-overlapped viruses to perform deep mutational scanning of each gene independently.
