Sentence examples for mutational alteration of from inspiring English sources

Also we found neither AKT2 nor AKT3 mutation in the corresponding sequences to the AKT1 E17K, indicating that mutational alteration of neither AKT2 nor AKT3 contributes to cancer development.

Mutational alteration of the Src-SH3 binding motif in the SBD effectively blocks the Src/p130Cas interaction [16], [18] and significantly reduces levels of p130Cas SD tyrosine phosphorylation [19], [20].

Each large exon contains its own start codon and 5' splice signal allowing the locus to encode several protein products independent of the mutational alteration of the ORF in one of the exons, so we would expect the exons B, C and D to be expressed in D. sechellia and D. erecta.

Supporting this view, worm lifespan can be increased by mutational alteration of metabolism in E. coli affecting respiration (Saiki et al, 2008).

The objectives of this study were to better our understanding of the carcinogenesis of gestational trophoblastic tumours and to investigate the possible presence of mutational alteration of the p53 tumour-suppressor gene in these tumours.

No somatic mutations leading to amino acid substitutions or frameshifts were found, indicating that mutational alterations of SIP1 are not main genetic events in hepatocarcinogenesis (data not shown).

We therefore performed mutational alterations of the positive charges in the putative S4 segment of Ci-VSP with the aim of shifting the voltage dependency to a more physiological region.

These findings suggest that mutational alterations of the p53 gene are involved in the development of a significant proportion of some ovarian carcinomas (SCAs or EAs), especially in advanced stages.

However, care should be taken in extrapolating findings from cases with mutational alterations to BRCA1 to those with potentially physiologically relevant variations in expression of different isoforms.

Here, we have analysed the coding sequence of TP53 in a series of brain metastases, confirmed by histopathology to derive from primary breast carcinomas, and we report a high frequency of TP53 mutational alteration in breast cancer metastatic to the brain.

In this sense, deletions, insertions and inversions of DNA coding regions are more dramatic events for genes because such mutational alteration may lead to a reading frame (RF) shift and to modification of the extensive region of amino acid sequence.