Sentence examples for mutational alteration in from inspiring English sources

Here, we have analysed the coding sequence of TP53 in a series of brain metastases, confirmed by histopathology to derive from primary breast carcinomas, and we report a high frequency of TP53 mutational alteration in breast cancer metastatic to the brain.

The molecular mechanisms underlying taxane resistance involve mutational alterations in the tubulin subunits, microtubule dynamics, phenotyping programming of the epithelial-to-mesenchymal transition landscape, and the status of AR activity.

RpsL K42R substitution was found not to affect the drug resistance pattern associated with mutational alterations in 16S rRNA H44.

The recent reports on the interplay of S12 on 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides prompted us to study in detail the role, if any, between RpsL K42R and mutational alterations in 16S rRNA helix 44 conferring resistance to 2-deoxystreptamines.

The function of this domain is unknown, but mutational alterations in this loop affect the localization of MalK Ec to the membrane bound MalF Ec [ 29].

Therefore, in order to obtain data on the relevance of the Ras-homologous GTPases in the formation and progression of breast carcinomas, we analysed Rho proteins as to mutational alterations in tumours.

Genetic screening of cell lines did not reveal any mutational alterations in the SIP1 gene, suggesting the implication of epigenetic regulatory mechanisms for the silencing of SIP1 in HCC.

To ensure stable complex formation of ClpC/MecA/ClpP, we used a ClpC variant (ClpC-DoubleWalkerB (DWB)) that harbours mutational alterations in the Walker B motif of both AAA domains and is thereby arrested in the ATP state.

Supporting this view, worm lifespan can be increased by mutational alteration of metabolism in E. coli affecting respiration (Saiki et al, 2008).

Each large exon contains its own start codon and 5' splice signal allowing the locus to encode several protein products independent of the mutational alteration of the ORF in one of the exons, so we would expect the exons B, C and D to be expressed in D. sechellia and D. erecta.

Mutational alteration of the Src-SH3 binding motif in the SBD effectively blocks the Src/p130Cas interaction [16], [18] and significantly reduces levels of p130Cas SD tyrosine phosphorylation [19], [20].