Sentence examples for mutational activation in from inspiring English sources

The question is whether other kinases play a role as well by mutational activation in glioblastoma.

The importance of this pathway and its frequent deregulation and mutational activation in cancers has led to development of small molecule inhibitors.

With the caveat that this is a limited dataset, this observation may suggest that these TKDs are the most 'vulnerable' to mutational activation in cancer.

57 primary tumour samples from Indian oral cancer patients with a 5-15 year tobacco chewing habit, were examined for mutational activation in codons 12, 13 and 61 of the H-ras, K-ras and N-ras oncogenes.

While the activation of Raf-1 requires a complex series of events, the activation of B-Raf is much simpler to achieve, explaining why B-Raf is a preferred target for mutational activation in human cancers (Mercer and Pritchard, 2003).

Although Ras genetic mutational activation is infrequent in breast cancer, Ras is often pathologically activated in breast cancer due to its link to the EGF receptor family or other tyrosine kinases that signal through Ras and that are commonly overexpressed in this disease (Kroll et al, 2002).

In conclusion, mutational activation of K- ras in SNC is restricted to a subgroup of the adenocarcinoma histology.

Although FGFR activating mutations are found in multiple other cancer types, including FGFR2 in endometrial cancer [ 54] and FGFR3 in bladder cancer [ 55], there is no evidence for common mutational activation of the FGFRs in breast cancer.

Studies of rare pancreatic cancer subtypes provide direct evidence for a conserved and acinar-specific role of β-catenin in humans: mutational activation of β-catenin signaling is observed in acinar cell carcinomas but not insulinomas (Abraham et al., 2002), suggesting that the former cancer exploits the proliferation control circuits of its untransformed precursors.

Although overexpression and autocrine activation of the Met signaling pathway are commonly found in human cancers, mutational activation of Met has been observed in small cell and non-small cell lung cancers, lung adenocarcinomas, renal carcinomas, and mesotheliomas.

Nucleotide sequence analysis revealed a single nucleotide mutation at codon 545 of PIK3CA in MKN1 and AGS cells (E545K and E545A, respectively, Additional file 11c), which suggested that AKT is potentially activated in these cells through mutational activation of PIK3CA.