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The P531A mutation would result in the loss of important hydrogen bonds, shown in Fig. 3a.
Y532 normally packs against the sidechain of pVHL H110 and the Y532C mutation would result in diminished van der Waals interaction.
Subsequent next-generation sequencing identified a nonsense mutation in AGBL1 in the 15q locus; this mutation would result in a premature termination of AGBL1.
It used to be assumed that this mutation would result in active Rab enzymes.
This mutation would result in out-of-frame, continued translation into the 3′-untranslated region (p.Tyr335Glyfs*113).
Our energy results showed the R213W mutation would result in destabilization but the standard deviation is significant.
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A virus crippled by immune escape mutations would result in reduced viral load and delayed disease.
Among these were 50 genes in which missense or frameshift mutations would result in an alteration of the gene product.
Five of the mutations would result in substitutions of serines at three positions (Ser 52, Ser 47 and Ser 22).
Gene mutations would result in observable differences - in cell patterns or in simple forms of behaviour, such as moving, eating, excreting or mating - and more or less linear relationships between genes and phenotype (the form of an organism) could be established.
In contrast, comparing the wt and mutants to one another and parameterizing the simulation using a geometric parameter, i.e. the degree of solvation of the buried interface, resulted in a testable prediction regarding which mutations would result in a stable dimer.
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