Sentence examples for mutation would lead from inspiring English sources

This mutation would lead to substitution of lysine for glutamic acid at position 681 (Glu681Lys), 51 amino acids downstream of the highly conserved DFG motif found in all protein kinases (Figure 4).

Previous studies in C. elegans, Drosophila, and rodents have revealed dozens of genes, whose mutation would lead to extended lifespan.

To test whether oncogenic Ras mutation would lead to UCC, we utilised mice carrying the constitutively active H-Ras Q61L oncogene ('low-copy').

Alteration of pre-mRNA splicing due to the JAK2V617F mutation would lead either to an inframe translatable mRNA species or to an out-of-frame mRNA, which most likely contains a premature termination codon.

First, we can simply count the number of sites atwhich a mutation would lead to a synonymous change, using fractional counts for sites at which mutations can cause either a synonymous or a nonsynonymous change.

Both Y195A and Y195F mutants were made in the context of V266H to determine whether the smaller Y195 to alanine mutation would lead to greater restoration of activity or if it would instead be a change that was too drastic relative to the more conservative change of Y195 to phenylalanine.

Much as Riedl had noted that at an organismal level most mutations would lead to deleterious, unviable phenotypes, a similar observation has been made at the level of gene regulatory networks by Davidson and Erwin (2006, 2010) and Erwin and Davidson (2009).

Therefore we tested if cactus mutations would lead to the expression of our AGFP reporter.

Pertinent to the phenotype, mutations would lead to loss of GLI3 repressor and PTC1-deficiency respectively.

Otherwise a continual accumulation of mutations would lead to deleterious effects and loss of fitness.

Given that presenilin appears important for cleaving proteins that are crucial at synapses, presenilin mutations would lead to synaptic dysfunction.