Our above analyses have relied on simple epidemiological models to gain intuition for how circulating sublethal deleterious mutations would impact patterns of influenza A/H3N2's antigenic evolution.
The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases.
The location of the mutation upstream of the C-terminus would impact both BBS3 and BBS3L, as this region is identical between the two isoforms (Fig. 1B).
Many AML types are characterized by mutations in C/EBPα and RUNX1, which would impact many of the binding sites described here.
However, it could also be due in part to higher mutation rates of microsatellites relative to SNPs, which would impact upon levels of LD (reviewed in [ 37]).
We appreciate that the referees are interested in how deleterious mutations would further impact the evolutionary dynamics of H1N1 in humans and H3N2 in pigs.
If some HARs regulate human-specific social and behavioral traits, then mutations would likely impact cognitive and social disorders.
We should mention that a compensatory mutation would have the same impact, since it would mask the effect of a YKU80 deletion.
Therefore, we would suggest that F1174L mutation would have a great impact on protein function which was in good concordance with the results obtained by Mossé et al. [ 26].
Considering the clinical impact of dystocia, a single gene mutation would be subject to purifying selection and would be selected against in the evolutionary process.
