Sentence examples for mutation without any from inspiring English sources

As a universal selection system for GT cells, a target-gene-independent selection system such as positive negative selection with subsequent elimination of the positive selection marker using piggyBac transposon or HR combined with mega-nuclease allows retention of the desired mutation without any trace of additional exogenous nucleotides.

As we know, the less-is-more evolution can be simply induced by a frameshift mutation without any indel events (not to mention repetitive indel events).

This interface allows to query for samples and mutations by various filter criteria, e.g. genes, samples, tissue, histology, or mutation, without any restriction in the number of filters.

Because populations evolution is according to Muller's ratchet, that is in the presence of deleterious mutation, without any recombination, but with selection and random drift.

In thyroid carcinoma-derived cell lines, it was observed that inhibition of BRAF signalling by BRAF kinase inhibitors or BRAF RNAi inhibits growth, transformation and tumourigenicity of cell lines harbouring BRAFV600E mutation, without any effect on apoptosis [ 15- 19].

There was a report of six patients from one large kindred who underwent total gastrectomy for CDH1 mutation without any evidence of gastric cancer from detailed preoperative imaging studies, including high magnification endoscopy with methylene blue chromoendoscopy and multiple random biopsies.

For the phenotype genotype associations, we compared PDB patients with post-zygotic mutations to patients with germinal mutations and without any mutation within the SQSTM1 gene, for the following items: total sALP levels, age at diagnosis, number of affected bones, and Renier's index.

Furthermore, by using whole-genome sequencing techniques, we might achieve easier mapping and identification of mutations without any complex and time-consuming genetic mapping (Zuryn et al. 2010).

Using a document classifier, the abstracts containing mutations without any impacts are removed and the remaining abstracts are classified into two groups of disease related and non-disease related documents, after which extracted mutations are listed for each group.

It corresponds to the repeated irreversible loss of the fittest class of individuals because of the accumulation of the deleterious mutations, the effective absence of beneficial mutations, without any recombination, but with the random drift [ 25, 12].

Therefore, despite deliberately evolving TEVCys by using a fitness valley, the nucleophile-permissive TEVSerX can also be accessed from TEVCys by nearly neutral mutations without any large drops in activity.