Sentence examples for mutation within an from inspiring English sources

A single nucleotide mutation within an immunodominant Gag CTL epitope in an animal with undetectable plasma viral RNA resulted in viral escape from CTLs, a burst of viral replication, clinical disease progression, and death from AIDS-related complications.

The objective of the current study was to determine whether the location of a driver mutation within an affected gene impacts the biology of metastatic colorectal cancer.DNA was collected from 165 randomly selected specimens of patients who underwent margin-negative resection of colorectal liver metastases with curative intent.

We used brains of the transgenic mice (11months) model expressing the familial Alzheimer's disease (FAD) as making V717I (valine to isoleucine) 'London' mutation within an APP-CT99 which encompasses the β amyloid (Aβ) sequence.

However, subject BR1427 already has an existing mutation within an HLA-matched epitope in NS2 close to the time of infection, which is unlikely to be due to T-cell pressure at this stage and may represent the transmission of a viral adaptation induced in the previous host.

First, reduced viral fitness caused by a mutation within an epitope can be reverted by subsequent mutations referred to as compensatory mutations.

The emergence of a resistance-conferring mutation within an evolutionary tuned system of functional and physical interactions can present enormous physiological challenges and can have broad phenotypic effects.

In addition, a compensatory RNA mutation within a defective RNA variant was found.

A mutation within a conserved surface cluster in this domain causes a defect in DNA replication that is suppressed by mutation of replication protein A (RPA).

The obtained results show that the α-stable mutation delivers more solutions than the classical normal mutation within a slightly better time budget.

Our hypothesis is that hemangiomas arise from an early somatic mutation within a critical gene for capillary angiogenesis.

The observation of a mutation within a tissue or tumor (i.e., a somatic mutation) is not synonymous with proof that mutations are causally related to the cancer.