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This suggests that the clinical outcome of women with germline mutations may vary depending on which gene is mutated, and even possibly on the position of the mutation within a particular gene.
In addition, a compensatory RNA mutation within a defective RNA variant was found.
The obtained results show that the α-stable mutation delivers more solutions than the classical normal mutation within a slightly better time budget.
A mutation within a conserved surface cluster in this domain causes a defect in DNA replication that is suppressed by mutation of replication protein A (RPA).
Our hypothesis is that hemangiomas arise from an early somatic mutation within a critical gene for capillary angiogenesis.
The observation of a mutation within a tissue or tumor (i.e., a somatic mutation) is not synonymous with proof that mutations are causally related to the cancer.
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A single nucleotide mutation within an immunodominant Gag CTL epitope in an animal with undetectable plasma viral RNA resulted in viral escape from CTLs, a burst of viral replication, clinical disease progression, and death from AIDS-related complications.
First, reduced viral fitness caused by a mutation within an epitope can be reverted by subsequent mutations referred to as compensatory mutations.
In both of the experiments, as in Fig 2B, the mutated primer contained two mutations within a 3 bp region.
While recombination can bring together multiple mutations within an organism, evolution in asexual populations depends on the sequential accumulation of mutations within a lineage.
Rarity of clonal mutations within a region does not, however, rule out selection in that region.
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