Sentence examples for mutation with two from inspiring English sources

So far, the only genetic manifestation of pheochromocytoma associated with WDHA syndrome was found being a NF1 gene mutation, with two cases reported in the literature [ 8, 18].

Bacterial flora after mutation with two combined mutation factors were cultured in 250 mL flasks containing 100 mL 9 K liquid medium with ferrous iron.

Mouse models bearing an ATM-S1987A mutation (equivalent of the human S1981A), expressed on an Atm−/− background, or S1987A mutation with two additional autophosphorylation site mutations (corresponding to human S367A and S1893A) showed no defects in ATM activation [ 51– 51].

In conclusion, this analysis provided to detect some molecular differences between primary metastatic and nonmetastatic CRCs, with K-Ras and p16INK4A statistically altered in metastatic tumours; particular gene combinations, such as coincidental K-Ras mutation with two methylated genes are associated to a metastogenic phenotype.

In the present study we show that treatment of Swiss 3T3 cells or lymphoblastoid cells derived from control or a Parkinson's disease patient harbouring a homozygous LRRK2(G2019S) mutation with two structurally unrelated inhibitors of LRRK2 H-11522 or sunitinib) induced dephosphorylation of endogenous LRRK2 at Ser and Ser, thereby disrupting 14-3-3 14-3-3 14-3-3

Given such a starting point, the probability of fixation of the derived antimutator allele in an asexual population is: (6) This is the standard diffusion approximation for the fixation probability for an advantageous mutation, with two modifications: s* = Δ U + 2μ (where Δ U is positive for an antimutator), and p0 = (1/ N a ) + [2μ(N a − 1)/ N a ]≃(1/ N a ) + 2μ.

The Island Melanesian E1a branches share a key mutation with one from the Philippines (nts 373), and the Melanesian E1b branches share 4 mutations with another branch from the Philippines.

Here, we would like to expand the clinical presentation and haplotype background of the p.Ser107Leu BICD2 mutation with five additional patients from two North UK families (Fig. 1).

Incorporation of TP53 mutation with nine other prognostic factors into survival analyses can better stratify AML patients into different risk groups.

All but four are mis-sense mutations, with two mutations affecting splice sites, another creating an in-frame deletion, and one creating a premature stop codon.

Notice that the standard test w·ar - a·r compares two genotypes having zero and two mutations with two others each having one mutation.