Sentence examples for mutation with significant from inspiring English sources

In order to find this rare mutation with significant reproducible results, many family members and matched controls are necessary.

We report a case of a 52 year old female with bilateral advanced adenocarcinoma of the lung harboring the delE709_T710insD mutation with significant clinical and radiographic response to treatment with afatinib.

Although the pig IGF2 gene has been characterised in detail including the identification of a point mutation with significant effects on muscling [ 24], there is only a fragment of the gene in the published pig genome sequence (Sscrofa10.2; [ 12]).

There were four mutations with significant differences in mutant allele frequency between the three panels (Table 3).

Somatic DNA mutations with significant predicted effects on protein function (according to Mutation Assessor) were found in only 2 samples (Table 1).

There was a significant difference between the frequency of EGFR T790M and other EGFR-activating mutations, with significant variability among cases (4.8 41.3 %).

The authors argue that mutations with significant "conditional Ka/Ks values" are not directly involved in the drug resistance and play accessory role.

In contrast, mutations with significant deleterious effects on fertility (e.g. in some cases of severe autism) are less frequently transmitted to subsequent generations.

This survey was later expanded to 210 cancer samples and it revealed more than 1 000 somatic mutations with significant variations in their patterns across the examined twelve cancer types [ 24].

All five mutations with significant PSSM and SIFT scores were loss-of-function mutants of the resistance gene that led to susceptibility to the causal agent of stripe rust, Puccinia striiformis f. sp. tritici (Table 2).

A total of 34 SNPs were identified as back-mutations to CGs, of which three had a significant iHs value (Table 3), which is higher than the fraction of mutations with significant iHs values in the control data (P = 0.011, Chi-square test).