Sentence examples for mutation with response from inspiring English sources

They identified no significant association of mutation with response.

This study also confirmed the inefficacy of cetuximab in patients with BRAF p.Val600Glu mutations, with response rates of 8% vs 38% for BRAF mutated and wild-type, respectively [ 24, 25, 27, 28, 51].

The paradigm in this work exemplified by combining PIK3CA mutations with response to PI3K inhibitors could be extended to other breast tumor subtypes and driver oncogenes.

Further work is needed to understand if the impact of NRAS is drug-specific but their work does highlights the importance of understanding the relationship of mutations with response to therapy (Mulligan et al., 2014).

Treatments are selected largely without regard for tumour mutation profiles, although recent evidence linking KRAS mutation with poor response to EGFR mAb (Amado et al, 2008; Karapetis et al, 2008; Lievre et al, 2008) now influences decisions in the clinic.

EGFR activating mutations associated with response to TKIs have been identified in DNA extracted from CTCs and in free ctDNA [70 73].

We were not able to show relation of PI3K mutations neither with response to trastuzumab nor with PFS and OS.

The primary goal of BEAUTY is to identify novel somatic mutations associated with response to neoadjuvant chemotherapy.

Clinical use of some newer or investigational drug therapies in cancer requires that primary tumors be assayed for specific mutations associated with response or lack of response [ 1- 5].

The absence of a K-RAS mutation was associated with response to panitumumab (PR vs SD vs progressive disease; P = 0.0028).

Recent analyses (Bell et al, 2005) of phase II and III trials for EGFR-TKI, in which patients were not selected based on their mutation status, have suggested that EGFR mutations are correlated with response to therapy but are not correlated with overall survival (OS).