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Combination of a key mutation with other secondary mutations results in high level resistance.
There was no correlation of ASXL1 mutation with other gene mutations studied (Table 2).
The report concerning interaction of ASXL1 mutation with other genetic alterations in the pathogenesis of MDS and its progression is very limited.
There was no association of TP53 mutation with other chromosomal abnormalities, including +8, +11, +13, +21, −5/del 5q) and −7/del 7q).
However, the association of ASXL1 mutation with other genetic alterations in the pathogenesis of MDS and their dynamic changes during disease progression remain unclear.
Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in patients with myelodysplastic syndrome (MDS), but the interaction of this mutation with other genetic alterations and its dynamic changes during disease progression remain to be determined.
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Moreover, genes with more exons tend to have more co-occurring mutations with other genes, and genes having lower local coherent network structures tend to have higher mutation frequency.
In all three patients, the initial selection of the N155H mutation was followed by its disappearance and replacement by a pattern comprising the Y143H/R/C mutations with other mutations (T97A in 3 patients, L74M in 2 patients and G163R and S230R in one patient each); RAL was stopped between months 6 and 12 in patient 1, with disappearance of the selected mutations.
In addition, the interaction of TP53 mutations with other genetic alterations in AML was largely unknown.
The association of TERT promoter mutations with other molecular alterations commonly seen in glioma is detailed in Supplementary Table 5 and Supplementary Figure 1.
COSMICMart (COSMIC BioMart) provides a flexible way to mine these data and combine somatic mutations with other biological relevant data sets.
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move with other
transfers with other
mutation with severe
mutation with defective
mutation with mitochondrial
mutation with clinico-pathological
mutation with restricted
mutation with tumour
mutation with significant
mutation with genomic
mutation with clinicopathological
mutation with metastatic
mutation with incomplete
mutation with many
mutation with high
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