Sentence examples for mutation with genomic from inspiring English sources

To gain a more accurate assessment of the relationship of STAG2 mutation with genomic instability, we tested the relationship of mutation with genome-wide copy number alterations measured as fraction of genome altered (FGA; percentage of clones on the array that reported significantly altered copy number).

Our results revealed a very high correlation of TP53 somatic mutation with genomic instabilities in ESCC.

In cancer genomes, the association of APOBEC mutations with genomic rearrangements suggests that replication stress, persistent DNA lesions and incomplete repair expose single stranded DNA that becomes a substrate for deaminases leading to clustered mutations.

This is the first detailed analysis on the differential relationship of BRCA1 and BRCA2 mutations with genomic instability in Ovarian cancer.

None of the empirical studies have investigated the presence of competing mutations with genomic sequence data, or examined the number of genotypes that may be competing at any given time, although Holder and Bull [ 23] did observe high frequency polymorphisms during experimental evolution of bacteriophage in the family Microviridae.

In the glioblastoma study, Parsons et al. (2008) integrated mutation analysis with genomic copy number analysis and identified three major signaling pathways with critical genes mutated in a majority of the studied tumors.

Briefly, the mutation was introduced into mouse embryonic stem cells by homologous recombination with a plasmid carrying the mutation with flanking genomic DNA sequences, followed by antibiotic selection of ES cell clones, blastocyst injections, and embryo transfer.

Here, we show that SPOP, the most commonly mutated gene in primary prostate cancer modulates DNA double strand break (DSB) repair, and that SPOP mutation is associated with genomic instability.

Because EGFRvIII mutation is associated with genomic deletion of exons 2 7, we sought to determine whether assessment of this deletion by DNA copy number data could serve as a surrogate for RNA-based determination.

BRCA1 and BRCA2 mutations are associated with genomic instability caused by defective cell-cycle checkpoint and DNA damage repair (Deng, 2006).

Of the 3 BRcasesases, 2 had a pathogenic mutation with 1 large genomic rearrangement.