Sentence examples for mutation which showed from inspiring English sources

This is confirmed by the clinical presentation of FRDA patients carrying the p.I154F mutation, which showed earlier onset and a more aggressive phenotype when compared to p.R165P patients [19], [20].

The S313A mutation seemed to be more severe than the K312A mutation which showed a mild rescue effect on the levels of 32S precursor rRNA.

Five of 129 patients who were never smokers had the K-ras mutation, while 24 of 193 patients who were current/former smokers had the mutation, which showed significant difference (P=0.0086) (Table 3).

The only extreme outlier in the group predicted to have lower binding affinity (the open mutant I36A in the closed complex 1nbf) involved the mutation which showed the weakest population shift (Table S4).

Unfortunately, the number of tumours studied and the rarity of mutations in relevant genes in ovarian cancer meant that there were very few tumours with activating mutations in our series, and no conclusions can be drawn from the one tumour with an activating KRAS mutation, which showed resistance to both EGFR inhibitors but only moderate sensitivity to PI3K inhibitors.

Finally, human HT1080 fibrosarcoma cells expressing the COMP p.D469del mutation, which showed the retention of mutant COMP protein (Supp. Fig. S6) also failed to demonstrate a conventional UPR (Supp. Table S2), thereby confirming consistency between relevant in vivo and in vitro models.

Utilizing the information about wild type, mutant, three neighboring residues and experimentally observed stability data, we have developed a method based on decision tree for discriminating the stabilizing and destabilizing mutants and predicting the protein stability changes upon single point mutations, which showed an accuracy of 82% and a correlation of 0.70, respectively.

It is interesting that the E. coli E259A and R288A mutations, which showed different ΔΔ Go values than in T. thermophilus, also showed different ΔΔ Go values when Phe-tRNAPhe and Tyr-tRNATyr were compared.

The results confirmed a dose-dependent increase in the ribavirin-associated transition mutations (C to U and G to A) compared with the other transition (A to G and U to C) and transversion mutations, which showed no dose dependent effect (Fig. 3c).

To understand the role of Mcl1 in kinetochore assembly, further experiments such as isolation of separation of function mutations, which show a defect in only maintenance of chromatin structures or DNA replication, might be required.

The various correlated mutations which show consistent overlap with motif pairs are shown in Additional File 6.