Sentence examples for mutation which resulted from inspiring English sources

In Mosdi1 R left flank, a point mutation, which resulted in an amino-acid substitution (H245L), is made to acquire carboxin resistance (Fig. 2c).

However, the R580A mutation which resulted in an increase in in situ transamidating activity also facilitated TG2's role as a pro-death protein.

Savage and colleagues [ 27] reported a dominant negative mutation of PPARγ arising from a proline-467-leucine mutation, which resulted in severe peripheral and hepatic insulin resistance, partial lipodystrophy (the loss/reduction of certain fat depots) and hepatic steatosis.

Performing a sequence of the five exons of the 5a-reductase type 2 gene, no evidence of mutation was obtained while a C to T mutation, which resulted in substitution of the phenylalanine residue by a leucine at position 804, was identified in exon 6.

Approximately 50% of NSCLC patients who received the first generation EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib developed the acquired T790M mutation, which resulted in the resistance to the first generation EGFR TKIs; the optimal treatment for EGFR TKI resistance has not been defined.

Disadvantages of conventional genetic algorithm for network reconfiguration that a large amount of unfeasible solutions are created after crossover and mutation, which result in very low searching efficiency, are completely overcome.

We have confirmed the efficiency of this approach with the identification of β-globin gene point mutation, which results in the reduced production of globin in an inherited hemoglobin disorder thalassemia disease.

Our study demonstrates a novel dominant-negative Kv11.1 mutation, which results in degraded non-functional channels leading to a LQT2 phenotype.

Tg2576 mice express human APP containing the familial Alzheimer's disease (FAD) Swedish mutation, which results in elevated levels of Aβ peptides [29].

Compared to most H5N1 viruses in China and southeastern Asia in 2002 2004, raccoon dog isolates exhibited a T/S156A mutation, which results in the loss of a glycosylation site [1], [6], [8].

To facilitate the identification of donor-derived melanophores, particularly from enz donors, we utilized hosts homozygous for the goldenb1 mutation, which results in pale melanophores that are distinct from wild-type melanophores [7], [61].