Sentence examples for mutation which reduces from inspiring English sources

CRISPR/Cas9-mediated knock-in of Rpt3-T25A mutation, which reduces endogenous proteasome activity, causes marked accumulation of cell cycle inhibitors such as p21Cip1 and p27Kip1 during S-to-G2/M transition and impedes cell proliferation.

We specifically asked whether human ZnT3 harboring the Y372F mutation, which reduces the ZnT3 80 kDa species, was dominant over the Y357F mutation, which increases ZnT3 80 kDa species.

In contrast, human ZnT3 harboring the Y372F mutation, which reduces the formation of the 80 kDa species, decreased its targeting by 35% ±14.3%(n = 3) with respect to wild type human ZnT3 (Fig. 4D).

In addition, we have also explored other means to enhance immunogenicity and safety, including the ΔsopB mutation, which reduces Salmonella-induced fluid secretion in the intestines [32], [33], [34] and enhances the immunogenicity of a vectored antigen [35].

The mouse PL/J strain carries the CD18 hypomorphic mutation, which reduces the expression of CD18 to 2% to 16% of wild-type levels [ 13].

Escherichia coli strain CA8404 was selected as the microbe because it carries the crp* mutation which reduces catabolite repression and thereby allows both the 5- and 6-carbon sugars produced from corn stover hydrolysis reactions to be metabolized simultaneously [ 9].

We identified one residue which, when mutated, appears to stabilize the ΔN-PINK1 product, leading to an accumulation of ΔN-PINK1 in cells, and one mutation which reduced PINK1 cleavage resulting in cells accumulating FL-PINK1.

The results were very similar to those for β1 in that the wild-type complex was inhibited by glycogen while the double-tryptophan mutation, which reduced the total activity by 70%, also completely abolished the inhibitory effect of glycogen.

It is intriguing that—unlike b g8, gu, and i-3 the i-3 thetation, which reduced viability, did not suppress growth (P = 0.936, Student's t-test; Figure 5C).

This pattern arises from clonal interference between competing mutations which reduces variability in the fixation process of adaptive substitutions [ 15].

Moreover, most mutants may only carry one or a few mutations, which reduces the chance to find improvements for which combinations of different mutations are needed.