Sentence examples for mutation which leads from inspiring English sources

Cells that are mismatch-repair (MMR -deficient have high rates of MMR -deficienthaveads to thighoratesof of mutationered proteins.

Analysis of partial sequences of Pdcyt b from both the azoxystrobin-sensitive parental isolate and the 28 azoxystrobin-resistant mutants revealed that a point mutation, which leads to the substitution at code 143 of alanine for glycine (G143A), is responsible for the observed azoxystrobin resistance in the laboratory mutants.

The Q148H mutation, which leads to a decreased activity of IN, confers a higher level of resistance to RAL than G140S or N155H.

CT-Tg mice over-express 100 amino acids of C-terminal fragment of amyloid precursor protein (CT) with London mutation, which leads to extensive neuronal degeneration in the hippocampal area [6], cognitive impairment [7] and destruction of long-term potentiation (LTP) [8].

Nevertheless, we hypothesize that the Axd phenotype results from a regulatory mutation which leads to increased expression of Grhl2.

The c.262delG mutation which leads to a frame-shift and truncated forms of glucose-6-phosphatase was present in three unrelated patients (one homozygote, two heterozygotes).

The 100,000 Genomes Project could help people like Alysia by identifying a specific mutation, which lead to taking part in future drug trials.

The first apoc2 mutant we selected had a frame shift mutation, which led to the amino acid sequence change in its Lpl-binding domain (Fig. 1B,E).

This effect was more obvious with the HX mutation, which led to a gain of interaction for all but one TF in this tissue.

They also identified a spontaneous point mutation, which led to alteration in RNA secondary structure and increased DNA methylation in its promoter region.

Although increased p53 staining is often indicative of a mis-sense mutation in p53 resulting in a stabilised mutant protein, there are other types of p53 mutation, which lead to decreased or loss of staining.