Sentence examples for mutation which introduces from inspiring English sources
This plasmid is identical to HIC except that it has a point mutation which introduces a stop codon at amino acid 164, immediately before the I-mfa domain.
The A66W mutation, which introduces a bulky hydrophobic side chain and induces massive vesiculation of liposomes in vitro, strongly impeded eye development, even in presence of the endogenous endoA gene.
It is comparable to the talpid 3 chicken loss-of-function mutation which introduces a frameshift in the orthologous region.
The most obvious surface distortion, whether statically or dynamically derived, is contributed by the V516I mutation, which introduces a methyl group into the active site cavity (Supplementary Figure S5).
In addition to the apoc2 mutant characterized in Figs 1- 4, we generated a second zebrafish line with a different apoc2 mutation, which introduced a stop codon in the target site, causing loss of the Lpl-binding domain of Apoc2.
The beneficial effect of complementation may be enhanced by efficient mtDNA replication, as provided by CR mutations which introduce alternative replication sites.
It is estimated that approximately one-third of all inherited disorders and some forms of cancer are caused by nonsense or frame shift mutations, which introduce premature translation termination codons (PTC) into the reading frame of mRNAs.
This action of antibiotics such as gentamicin can be used for therapeutic purposes in genetic diseases that arise from point mutations which introduce premature stop codons (UAA, UAG, UGA) into coding sequences [ 6, 7].
If so, we expect cancer transcripts to: (A) have a higher incidence of nonsense or frameshift mutations which introduce a premature translation termination codons to mRNAs resulting in truncated proteins or more often rendering them vulnerable to nonsense-mediated decay (13, 14).
The effect is even more pronounced for the mutation G1885E, which introduces an acidic residue into the DR3 domain in substitution of glycine.
The one exception to this is an early study of another stabilizing mutation, [P12W], which introduces an additional aryl/aryl interaction and results in more apolar burial.
