Sentence examples for mutation which interfere from inspiring English sources

However, this phenomenon is reversed by over-expression of INO80mt (E653Q, a DEAD/H box point mutation) which interfere with INO80 ATPase activity.

One of the breeds, the Piedmontese, is extremely muscular due to a missense mutation which interferes with the function of the muscle growth repressing MYOSTATIN (MSTN) gene.

In response, we have examined in detail other mutations that mimic the allosteric effects of the BiPADDA (to lock BiP in the domain uncoupled configuration) and found that unlike the BiPADDA mutation, which interferes with oligomerisation, these domain-uncoupling mutations (BiPT37G and BiPG226D) are more prone to oligomerization (new Figure 5 and its supplements).

These sequences are not heritable but can cause mutations which interfere with brain functions and can contribute to the development of psychiatric disorders [ 9].

DBA is caused by mutations in ribosomal proteins (RPs), most frequently in RPS19, which interfere with rRNA processing and ribosome biogenesis.

On the basis of X-ray crystallography, mutations were introduced into the FKH domain of Foxp3 which interfere with the interaction of FKH to the RSD of NFATc2 [ 66].

Approximately 50% of imatinib-resistant CML patients carry a resistance-associated point mutation in BCR-ABL, which interferes with imatinib binding.

However, in other instances, mutations create a mutant protein ("poison peptide") which interferes with normal function or assumes a new function.

The prototypic amino-acid substitution (T315I) produces a steric hindrance in the ATP-binding pocket of the kinase, which interferes with insertion of imatinib into the cavity ('gatekeeper mutation').

Cognitive impairment, including dementia, which interferes with trial participation.

It is difficult to analyse the function of these deletion mutants because they coexist with some point mutations, which may interfere with the outcome.