Sentence examples for mutation which increases from inspiring English sources

Conversely, the A352D mutantmutant (a mutation which increases cGMP selectivity in eukaryotic channels) increased both the affinity and the sensitivity for cGMP relative to the WT channel, again leaving those for cAMP unchanged.

Our model explains well the effect of CDK9 S175A mutation, which increases the association of the mutant CDK9 with HEXIM1 suggesting more efficient 7SK snRNP formation.

We specifically asked whether human ZnT3 harboring the Y372F mutation, which reduces the ZnT3 80 kDa species, was dominant over the Y357F mutation, which increases ZnT3 80 kDa species.

A back mutation is defined as a mutation which increases the fitness of a genotype as in [ 8].

At this equilibrium, the trait variance is maintained by mutation, which increases variance, and by genetic drift and stabilizing selection, which decrease variance.

The first gltA mutation, which increases CS activity by disrupting NADH-inhibition of this enzyme, is beneficial for growth on the acetate and contributed to preserving the rudimentary Cit+ trait from extinction when it first evolved.

Within the N-terminal region, the largest effects on γ-secretase cleavage activity were found with loss of the polar N8 residue, which increased Aβ40 to nearly 300% and Aβ42 to 180% of that of wt, and the L14A mutation, which increased Aβ40 to ∼160% and Aβ42 to >200% of that of wt.

Although the mechanism for this association remains elusive, some hypotheses have been proposed to explain it, including gain of function caused by GBA mutations, which increases α-synuclein (α-syn) aggregation, loss of function due to lysosomal enzyme deficiency, which affects α-syn clearance, and even a bidirectional feedback loop, but each of these hypotheses has its limitations.

The adaptation was acquired by two mutations which increased binding (VP1 T125K) and replication (3A E41K), respectively.

Mutations which increase the replication of dengue viruses in cell culture would greatly facilitate the manufacture of both a live attenuated or inactivated dengue virus vaccine.

Women who have tested positive for inherited BRCA gene mutations, which increase their risk for developing a new breast cancer in their other breast, are sometimes advised to consider contralateral mastectomy.