Sentence examples for mutation which decreases from inspiring English sources

The S308V mutantmutant (a mutation which decreases cGMP selectivity in eukaryotic channels) decreased both the observed cGMP binding affinity and the sensitivity to cGMP relative to the wild-type (WT) channel, leaving those for cAMP unchanged.

The opposite may be true for "protective" APP mutations (thicker stones, more resilient to risk factors) like the recently discovered Icelandic mutation which decreases APP processing [ 69].

They showed that mutations which decreased in vitro RNase H activity greatly increased resistance to AZT and d4T [11].

Hyperproliferative mutations which decrease the generation time are appropriately factored into the value of R. Lineages with n mutations also increase their numbers by initiation events: i.e., mutations from the lineages with n−1 oncogenic mutations.

Some combinations, such as the triple mutant I161V / F330Y / G368A which combines three mutations which decrease the catalytic efficiency of the enzyme, have a drastic effect on enzymatic activity (Fig. 1).

First large populations have an increased supply of beneficial mutations each generation, which decreases the waiting time for new advantageous mutations.

The Ser158Arg mutation (Ser145Arg for H3 numbering) in PR8mut has been described as a compensatory mutation in PR8 virus possessing the Lys165Glu mutation in HA (H3 numbering), which decreases the receptor binding avidity and replication kinetics of the virus [ 61].

That is why construction of the stably maintained mob- derivative of RSF1010 (the derivative carrying mutation(s) in mob locus, which decreases mobilization frequency significantly) could have important practical application.

For example, a cold-sensitive spt5 mutation is suppressed with 6-azauracil, which decreases the rate of transcription elongation (Hartzog et al. 1998).

Further progression entails loss of expression or mutations in P16 and P53, which decrease their function.

In contrast, all the mutants were found to have altered NADH ferricyanide reductase (NADH FR) activity with mutations affecting both kcat and KNADHm, which decreased and increased, respectively.