Sentence examples for mutation which confers from inspiring English sources

The doctor searched for and found a donor who had a rare genetic mutation which confers immunity to HIV infection by disabling a protein on cell surfaces to which the virus attaches itself in order to gain entry to a cell.After the transplant, the virus seemed to disappear from Mr Brown's body.

However, the extent to which [11C]erlotinib PET could identify NSCLC tumors that harbor other commonly detected TK mutations, such as the activating exon 21 L858R point mutation and the T790M gate-keeper mutation, which confers resistance to TKI therapy, has not been reported.

To investigate specific inhibition of drug-resistant HIV-1 by RNA interference, we designed siRNA molecules that recognize codons 181 188 of the reverse transcriptase (RT) gene of wild-type HIV-1 and HIV-1 carrying the M184V mutation, which confers high-level resistance to the RT inhibitor lamivudine.

Adding D will even give an advantage if there is a third mutation which confers resistance to both K and D (but not I).

The child HIV variant evolved shortly after treatment with 2 NRTIs to a predominant species also carrying the G190A mutation, which confers resistance to all NNRTI, albeit in the absence of NNRTI selective pressure.

Xcv 85* [54] and 85* ΔhrcV, strains carrying the hrpG* mutation which confers constitutive hrp gene expression [54] were cultivated overnight at 28°C in MOKA rich medium [74] or in secretion medium (MA) [75].

These viruses were carrying the H275Y mutation, which conferred resistance to oseltamivir (2 ).

Of note, the T315I mutation, which conferred cross resistance to both imatinib and dasatinib in preclinical models, was identified in four of six patients who were resistant to dasatinib therapy.

Cell-block processing allowed for the performance of EGFR mutational analysis in 60% of our patients with a diagnosis of metastatic adenocarcinoma and in two of them confirmed the presence of an EGFR mutation, which confer sensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib [ 20].

Analysis of protease susceptibility, however, revealed that mutations, which conferred protease resistance, simultaneously diminish thrombin inhibition activity.

These risk calculators, and the task force's measured recommendations, do not apply to women who have the BRCA-1 or BRCA-2 gene mutations, which confer an extremely high risk of developing breast cancer, and they don't apply to women younger than 35 or older than 79.