Sentence examples for mutation which caused from inspiring English sources

One example is the A217P mutation, which caused a complete loss of TGR5 activity as measured by the luciferase assay, pointing to a crucial role of the third intracellular loop for TGR5 function.

As a result of DNA sequencing of purified B cells, we found one nucleotide deletion mutation, which caused a frame shift after the amino-acid residue 251, in half of the DNA.

According to the DNA sequence analysis, the c.1254C>T genetic variant is a synonymous mutation, which caused by C to T mutations in exon 11 of human XRCC1 gene (p-serine (Ser) 418Ser).

Our DNA sequencing analyses suggest that the p.Gly14Ala is a nonsynonymous mutation, which caused G→C mutation in exon3 of VDR gene and resulted into Gly to Ala amino acid replacement (p.Gly14Ala, reference sequences, GenBank IDs: NG_008731.1, NM_000376.2, and NP_000367.1).

In a different apoc2 mutant line, we found a stop codon mutation, which caused deletion of the Lpl-binding domain from the Apoc2 protein sequence (supplementary material Fig. S3).

As for p.His305Gln, our DNA sequencing analyses indicate that it is also a nonsynonymous mutation, which caused C→G mutation in exon9 of VDR gene and resulted into His to Gln amino acid replacement (p.His305Gln, reference sequences, GenBank IDs: NG_008731.1, NM_000376.2, and NP_000367.1).

A third category has a so-called "nonsense mutation," which causes the cell to abruptly terminate production of the protein, making only a fragment.

The reason might be that they have a gene mutation which causes more connections between different brain areas, so there is more cross-wiring than with others.

Another difficulty was identified in the case of the recessive muscoides (mus) mutation, which causes dwarfism.

Both strains carry the Os mutation which causes reduction in nephron number.

The most common is the c.271dupA mutation, which causes a frameshift truncation, accounting for 42% of pathogenic alleles (Ref. 14).