Sentence examples for mutation which allowed from inspiring English sources

Additionally these embryos carried a homozygous SOX2flox mutation, which allowed authors to excise SOX2 using lentiviral Cre recombinase virus.

Thus, we focused on the C-terminus of the protein and generated N-terminally GST-tagged C-terminal fragments of MeCP2 (amino acids 274 340) with and without the R306C mutation, which allowed us to uncover more subtle differences without the overwhelming DNA binding of the MBD.

One of the reasons why antibodies have such good binding parameters is that in vivo they are subjected to rounds of expansion, selection and mutation which allow them to evolve with repeated exposure to the challenging agent.

Most laboratory strains of A. nidulans carry the veA1 point mutation, which allows asexual spore production in the absence of light (Kim et al. 2002).

The greater sensitivity of HRM allowed longer amplicons to be used (534 base pairs was successfully used for the region surrounding the 6174delT mutation) which allows for the screening of unknown mutations as we have demonstrated.

This expansion included the following: Two enabling characteristics: Genome instability and mutation, which allows changes in one cell to pass to daughter cells through mutation or epigenetic changes in the parent cell DNA.

In combination with a zll mutation, which allows AGO1 greater access to miR165/166, increased levels of SQN in Ler-0 enhance repression of AGO1 targets, such as the Class III HD-ZIPs, and lead to a high frequency of terminal stem cell differentiation.

Therefore, additional marker strains were constructed containing several auxotrophic mutations, which allowed the determination of genetic distances between these markers.

This led to strong telomerase activity in the cells with mutations, which allowed them to maintain longer telomeres.

We also generated a plasmid with two tracer mutations, which allowed us to prepare mixtures with different, defined amounts of wild type and mutant plasmid before sequence analysis, in order to determine the sensitivity of the sequencers for picking out the occurrence of the introduced SNPs.

There are no signature genetic mutations which allow a reliable clinical diagnosis.