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Older age, proximal location and BRAF mutation were significantly associated with CIMP-high in both MSI-high and non-MSI-high tumors.
By univariate and multivariate analysis, 2nd-line chemotherapy, and L858R mutation were significantly related to poor PFS and OS.
Serum and urinary THP concentrations of all available patients with UMOD A247P mutation were significantly lower than those of controls.
As expected, patients with tumors harboring p53 DNA binding domain mutation were significantly associated with poor survival (p = 0.0117).
In the current study, we report that women with a BRCA1 (versus BRCA2) mutation were significantly more likely to die of their disease.
In keeping with this observation, patient fibroblasts carrying the p.Ser59Leu mutation were significantly less sensitive to staurosporine‐induced apoptosis compared with control cells.
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Nevertheless, both the fraction of mutated mRNA and protein for this mutation are significantly below 50%.
In Germans/Croatians, the frequency of the mutation was significantly increased in mothers with preeclampsia compared to controls.
Consistent with our previous observation, the binding of calnexin C-tail to the rIII-IV linker (+25) containing the GAERS mutation was significantly decreased by 82% (p < 0.001) compared to the wild-type rIII-IV (+25) (Fig. 6B and C).
"We found that the mutation was significantly more common in men with a family history and early diagnosis compared with men diagnosed later, after age 55, without a family history.
In these core isolates the Y976F mutation was significantly more prevalent in Indonesian isolates (96%, 24/25) compared to Thai isolates (43%, 3/7); p = 0.004.
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