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Furthermore, the true prevalence of nondeletional mutations and Thailand type (− THAI) deletion mutation were first reported in this study.
Univariate exploratory analyses of the relationship between the protective efficacy as measured in the trials and the measure of resistance (day 14 ACPR, frequency of triple dhfr mutation, frequency of dhps double mutation and their combination in a quintuple mutation) were first undertaken using non-parametric methods (Spearman's rank correlation) using Stata v10.1.
Attempts to obtain mice reconstituted with a human immune system (HIS) mice, also referred to as HIS mice, date back to the end of 1980s, when mice carrying the Prkdcscid mutation were first used as recipients of human progenitors, with limited success (Shultz et al, 2007).
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In 2008, the R132H IDH1 mutation was first found in human glioblastoma multiforme [55].
To test this, the pdc2Δ519 mutation was first integrated by transformation and homologous recombination into the genome of the commercial EC1118 and the native Mab2C wine yeasts.
This process of evolution of activity by selection and mutation was first utilised ex vivo in phage display technology [2] and later using yeast or bacteria as vectors.
This mutation was first identified in families with aminoglycoside-induced deafness, and the ototoxic susceptibility was attributed to enhanced binding affinity to aminoglycosides of 1555A>G rRNA (Qian and Guan, 2009).
This mutation was first reported by Benson et al. who found similar electrophysiological defects in tsA201 cells [16].
An example of this may be an escape pattern where a primary mutation is first selected in context of a specific HLA allele, followed by a compensatory mutation at a secondary site [24], [35], [36].
The mutation was first mapped on chromosome 3 by bulk segregation analysis (BSA).
The p.M1T mutation was first reported in another Chinese study from Hong Kong in 2004 [ 23].
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