Sentence examples for mutation we suggest from inspiring English sources

From the effects of this mutation we suggest a novel role for domain 3b of Munc18-1 in regulating neuronal exocytosis.

However, because the RNAi depletion of Mrg15 in the salivary gland and in nurse cells (using two different RNAi-transgene systems) gives similar results as the Mrg15 j6A3 mutation, we suggest that it is highly unlikely that a second-site mutation on this chromosome is responsible for suppression of condensin phenotypes in the salivary gland and enhancement of condensin phenotypes in nurse cells.

As most studies have focused on HPV infection and TP53 mutations, we suggest that more research should be performed using whole genome or next generation sequencing to determine the true landscape of genetic and epigenetic alterations in vulvar squamous cell carcinoma.

While our study cannot distinguish between meiotic and mitotic mutations, we suggest that meiotic errors are likely to be more important.

Having excluded these mutations, we suggest that this PRA segregating in Border Collie is a new XLPRA (XLPRA3) and propose it as a potential model for the homologous human disease, X-Linked Retinitis Pigmentosa. X-Linked Retinitis Pigmentosa

Given the comparable frequency of BRCA1, BRCA2 and TP53 mutations among patients diagnosed at ≤ 35 years and the high penetrance of TP53 mutations, we suggest that all patients who develop breast cancer at ≤ 35 years of age should be offered genetic counseling and a family history of LFS-linked cancers should be carefully obtained.

As an alternative to a series of gain-of-function mutation events, we suggest that the metastatic mesenchymal phenotype can arise from malignant myeloid cells either through cell hybrid formation or through direct transformation of tissue macrophages.

As TTHL is an electrophilic molecule with a polar group at either 3-OH, 6-OH, or 16-OH positions, and was capable of inducing frameshift mutation (Table  4), we suggest TTHL is a weak intercalator mutagen.

As with the alternative mutations in PCHAS_011370, we suggest that these two alternative ubp1 mutations are partially selected (by CQ treatment) in the uncloned parasite AS-15CQ.

Based on the in vitro studies that show greater FGFR-dependence of the tumour cell lines with FGFR fusions than those with point mutations (2, 3), we suggest that the presence of a fusion protein may be a useful predictive biomarker in the selection of patients for FGFR-targeted therapy.

Using our observations on specific packing, we suggest mutations to an engineered HIV RNase-H to make its function better.