Sentence examples for mutation we had from inspiring English sources

For the E109K mutation we had 14 homozygotes and 2 heterozygotes (Table II, Supporting Information Fig. 2s).

In previous studies of the Tau-ΔK280 mutation we had noticed pronounced aggregation, but it was not clear in what pathway the major effect of mutant Tau was located.

As the 17q25.3 gain was the most frequent gain in our BRCA1-mutated population, and has not yet been described in the context of BRCA1 mutation, we have decided to characterize it further.

To test whether protein dynamics contribute to activity enhancement in the V67L mutation, we have studied the conformations and dynamics of the minimized and engineered intein ΔΔIhh-V67CM and a single V67L mutant, ΔΔIhh-L67CM, by solution NMR.

By generating a knock-in mouse model expressing non-phosphorylatable Separase with a S1121A point mutation, we have explored the Separase phospho-regulation at organismal level.

By neuron-specific over-expression of APP with the swedish double mutation (APPswe, K670N + M671L) and PS1 carrying the M146V mutation we have generated a double transgenic mouse line, ARTE10, which can be maintained homozygous for both transgenes.

A representative low-cost mutation we have isolated is in the translation elongation factor EF-G.

The functional consequences of the mutation we have found may help explain why the tumour arose.

To facilitate the structural analysis of missense mutation, we have incorporated the Jmol software (33) in the MSV3d interface.

The mutation we have found may similarly affect PTEN activity, finally resulting in increased PKB activity, increased cell proliferation, and diminished apoptosis.

Future research will undoubtedly identify such C-2 domain-interacting molecules, most likely further explaining the oncogenic nature of the PTEN mutation we have described here.