Sentence examples for mutation we found from inspiring English sources
For non-mutated individuals and patients homozygous for the germinal SQSTM1/P392L mutation, we found about 3%% of contamination.
Interestingly, the mutation we found was in homozygous state (Figure 1B), which is not expected for a protein that acts in a dominant fashion.
The novel Trp1197Stop mutation we found in subject N1 is one of the best examples of functional SNPs of this kind.
In contrast to EGFR mutation, we found no individual SH2 domains whose binding correlated strongly with RAS mutation status by rosette or far-Western blotting.
When extending this model to incorporate selection amongst strains that are continuously generated through mutation, we found that simple forms of selection will lead to simple predictions for the probability of replacement of new strains.
Regarding mutation, we found that the most abundant OTUs are generally composed of a unique RST with the highest numbers of tags characterized by exact matches to sequences in GenBank (100% if it is a known species), and a few other unique RSTs with lower numbers of tags and correspondingly lower matches to sequences in GenBank.
"Most of the mutations we found we can see in the field, and we are even seeing them in combination," he said.
Most of the somatic mutations we found have been reported, including mutations in EGFR, KRAS, BRAF, and PIK3CA [11] [17][11] [17].
Among 35 detected mutations we found 30 transitions, 3 transversions, 2 deletions (frameshift), 3 nonsense (stop), 26 missense and only 4 were synonymous.
Filtering for homozygous mutations, we found approximately 5% of all SNPs with sequencing coverage rates greater than 8-fold and we were able to repeatedly detect approximately 90% of the mutations in both snap frozen and FFPE tissue preparations.
Despite small sample sizes (6 FTLD-TDP patients with GRN mutations, 10 FTLD-TDP patients without GRN mutations), we found that both subgroups had a significantly "older" gene expression profile than neurologically normal controls of the same chronological age.
