Similarly, regarding the results with the CYP2C9D mutant, we emphasize that this mutation is modestly structurally different than the wild type CYP2C9 in crystal structures, although the mutant binds and metabolizes ligands with similar catalytic properties.
Because mutations associated with node removal are likely to generate incomplete fragments or nonfunctional gene products (Zhong et al. 2009; Wang et al. 2012), we emphasized only on edgetic perturbation (due to deleterious mutations) model for further investigations.
We emphasized quality over quantity".
We emphasized the sampling of cave populations.
We emphasized two key points.
We emphasize that our approach clusters mutations according to the uncertainty in their ancestry as determined by the uncertainty in the frequency of individual mutations.
Building upon earlier studies; however, we emphasize the increased risk in individuals with mutations at both the 5′ (543-713) and 3′ (1310-2011) regions of the APC gene.
In addition, we emphasize the need for a comprehensive analysis of mtDNA mutations and their effects on cellular function in different aging human stem cell populations.
Although such a compensatory roles most likely provided selective advantages that were subject to adaptive evolution, we emphasize that the recruitment mechanisms crucially involved (slightly) deleterious mutations, and were hence nonadaptive in nature.
We emphasize that NMF simultaneously detects the signatures present in the somatic mutation catalogs of multiple tumors and determines the contribution of each signature to the somatic mutations in each tumor.
