This mutation is yet to be identified.
Several VAPB mutations have been identified, but so far only a P56S mutation is yet known to co-segregate with disease [ 8, 9].
The fact that one person with the exon 21 mutation developed breast cancer and the other two with the exon 21 mutation are yet free from the disease suggest that the six common polymorphisms and the intron 7 variations are unlikely to predispose to or protect from the disease in exon 21 mutation carriers.
Although the molecular basis of the o7 mutation is yet unknown, it was shown that this mutation, in addition to repressing the lower molecular weight α-zeins, drastically affects the development of maize endosperm due to a reduction in starch content.
It is likely other CHEK2 founder mutations are yet to be discovered, as to date, CHEK2 has not been thoroughly investigated in many ethnic groups.
In the other seven JS patients, a second mutation was not yet identified (Table 1, Table 1 source data 1).
Next, mutation Cx32P87A is yet another cause of the CMTX disease; nonetheless it forms functional channels with properties that differ mildly from those of wild−type controls when expressed in pairs of Xenopus oocytes [23], [49].
However, the association between body size and CRC risk for MMR gene mutation carriers is yet to be established.
> -wrap-foot> In the field of molecular evolution, there are commonalities behind disease mutations which have been detected, but there are more complexities to disease mutations, which are yet to be discerned.
Although this is the cytoplasmic form of the enzyme, it is closely related to the mitochondrial form, and the physiologic significance of this mutation is not yet determined.
