Sentence examples for mutation was validated from inspiring English sources

Each mutation was validated using the mutation validation tool available on IARC TP53 database (http://www-p53.iarc.fr/).

The pathogenic effect of this mutation was validated by knockdown of ap1s1 expression in zebrafish by a morpholino, resulting in perturbation in skin formation, reduced pigmentation and motility deficits.

Representative samples are shown in Figure 5. PTEN loss and mutation were validated by immunohistochemistry. PTEN staining was negative in all cases in which NGS revealed a homozygous deletion or mutation.

Given this number of sensitive positions predicted by our evolutionary analysis, the mutation is validated as being responsible for the AI and this region as playing an important role during enamel matrix formation.

The robustness and statistical significance of the clusters and mutations was validated by averaging over ten 2 1 training/test bootstrapped datasets on which we repeated the complete clustering analysis.

The analytical sensitivity of MPP for EGFR mutations was validated to a limit of detection of 1.25%.

Subsequently, the HRMA of KRAS mutations was validated in a set of DNA obtained from several cell lines (Table 1) with or without a known KRAS mutation.

The association between low RIC8A expression and TP53 mutations was validated by the analysis using qRT-PCR of 38 tumours from the early stage cohort [ 7].

The introduced mutations were validated in-house and in 44 laboratories using various techniques, including next-generation sequencing.

Presence and type of mutations were validated by sequencing in 111 samples.

Detected mutations were validated by direct sequence.