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Exact(6)
Except for exon 1, which encodes only 10 amino acids, the entire coding sequence was deleted and the mutation was therefore expected to be a null allele.
The slc127 mutation was therefore renamed arp9-127.
Disruption of the activity by this mutation was therefore causing other defects in the functionality.
The percentage of analyzed recurrent tumors bearing a mutation was therefore surprisingly low.
The D820N mutation was therefore introduced to assess if this residue indeed played a role in catalysis.
One PIK3CA mutation in sample P72_pos was called at 1% allele frequency by NGS, and this mutation was therefore unlikely to be detected by Sequenom analysis.
Similar(54)
An approximately optimal value of the fold increase α in mutation rate due to a mutator mutation is therefore given by αoptimal = kmut optimal/kmut.
The p.Leu77Arg but not p.Val101Met GCK mutation is therefore considered a pathogenic mutation associated with MODY.
The His170Ala mutation is therefore expected to modify the stability and charge of Asp187, altering in turn the spectral properties of the neighboring Trp347.
This mutation is therefore likely to be an immune escape variant.
The heterozygous germline T294M mutation is therefore homozygous within the pancreas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com